The UCLA Jonsson Comprehensive 癌症中心 and the department of urology at the David Geffen 医学院 at UCLA have been notified that their standing as a National 癌症 Institute Specialized Program of 研究 Excellence (SPORE) site in prostate cancer has been renewed for another five years.
皇冠hga025大学洛杉矶分校的项目由首席研究员领导 Dr. 罗伯特Reiter, Bing Professor of Urologic 研究 and a member of the Jonsson 癌症中心.
This renewal marks the beginning of a third five-year cycle of funding that will support UCLA scientists' efforts to improve the prevention, 前列腺癌的检测与治疗. Thirty-thousand American men are expected to die from the disease this year, NCI估计超过238例,2013年将有000名男性被诊断患有前列腺癌.
The SPORE program is a central component of NCI’s efforts to spur collaborative, 美国各地学术中心的跨学科癌症研究.S., with the goal of translating basic research from the laboratories into patient care more quickly and effectively. 5年期债券，11美元.6 million grant will help UCLA expand its renowned prostate cancer program, which engages researchers and clinicians from many disciplines across campus to uncover the mysteries of the disease.
"The SPORE grant will robustly continue the outstanding programs we have developed over the last two cycles of the grant and give us the resources to bring investigators together for new innovative and multidisciplinary projects with the goal of improving the way we diagnose and treat prostate cancer,” Dr. 马克Litwin，教授兼主席 皇冠hga025大学洛杉矶分校泌尿科.
"This renewal of the UCLA prostate SPORE is indicative of the world-class research we have on this campus,” Dr. Economou詹姆斯, 皇冠hga025大学洛杉矶分校副校长兼微生物学教授, immunology and molecular genetics; molecular and medical pharmacology; and surgical oncology.
"The renewal of this SPORE grant is affirmation of the leadership role UCLA continues to play in groundbreaking research on prostate cancer,”医生说。. Eugene Washington, vice chancellor for health sciences and dean of the Geffen 医学院.
"Over the past 10 years, the UCLA prostate SPORE has had some great successes," Reiter said. 其中包括由Dr. 查尔斯·索耶斯博士. 迈克尔·荣格(Michael Jung)博士对前列腺干细胞的鉴定. 欧文·维特和他的同事, and the discovery and development of antibodies against the prostate stem-cell antigen gene, 这些都是从发现到临床试验的. 其他亮点包括. 吴宏肿瘤抑制基因PTEN的研究, demonstrating that the gene negatively regulates prostate cancer stem cell self-renewal, 增殖与生存, 和博士的工作. Bill Aronson and colleagues demonstrating that dietary changes can affect the growth rate of prostate tumors."
根据NCI, SPORE grants are designed to promote collaboration among the best scientific minds. The grants bring together researchers who might not otherwise have a chance to work together. The UCLA prostate SPORE is the only one in California and one of a handful in the U.S.
- Conducting translational research to investigate what makes prostate cancer spread and become castration resistant, 也就是说它对激素治疗没有反应.
- 靶向癌症干细胞和信号通路.
- Evaluating the effects and mechanisms of dietary change in preventing prostate cancer.
- Providing organizational infrastructure and novel technologies to support SPORE objectives.
- Developing new research areas and supporting the careers of new researchers.
- Dr. 罗伯特Reiter和Dr. Anna Wu will focus on translating N-cadherin-targeted antibody therapy into the clinic. N-cadherin, 一种在前列腺癌中广泛表达的蛋白质, is required for castration-resistant prostate cancer to emerge and survive, and it therefore is considered a credentialed target treatment for prostate cancer by the NCI.
- Dr. 吴宏及博士. Matthew Rettig will work to advance the management of castration-resistant prostate cancer by blocking the P13K and MAPK signaling pathways. An overarching hypothesis of this project is that prostate cancer can be classified according to alterations in signaling pathways — the mechanisms that underlie the formation of tumors. Individual tumors need to be classified according to which pathways are involved and must be treated with combination treatments that prevent an alternate pathway from being activated when one is blocked.
- Dr. 欧文·维特博士. Matthew Rettig和Dr. 安德鲁·戈尔茨坦将专注于前列腺癌干细胞, which are thought to be resistant to castration and most conventional therapies. Their overall rational is that optimal cancer therapy requires targeting the bulk of differentiated or adult cancer cells as well as the cancer stem cells. 该项目将重点关注一种名为Trop-2的基因, 哪些存在于正常和恶性前列腺干细胞上. 这是一种治疗前列腺癌的新方法.
- Dr. Bill Aronson和Dr. Pinchas Cohen will focus on the molecular effects of diet and how diet can help prevent and manage early prostate cancer. A previous study led by Aaronson and Cohen found that a low-fat diet supplemented with fish oil could slow the growth of prostate tumors.
约翰逊癌症中心主任. Judith Gasson, 医学教授兼研究高级副院长, said that UCLA's prostate cancer program is a shining example of the campus's excellence in interdisciplinary research.
"We'll be able to move forward more quickly now to develop new and better ways to prevent, diagnose and treat prostate cancer with the goal of saving tens of thousands of lives every year,她说.
